10,12-TRICOSADIYNOIC ACID

Name	10,12-Tricosadiynoic acid
Synonyms	TIMTEC-BB SBB009036 10,12-Tricosadiynoicaci 10,12-Tricosadiynoic acid 10,12-TRICOSADIYNOIC ACID tricosa-10,12-diynoic acid
CAS	66990-30-5
InChI	InChI=1/C23H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23(24)25/h2-10,15-22H2,1H3,(H,24,25)

Molecular Formula	C23H38O2
Molar Mass	346.55
Density	0.938g/cm³
Melting Point	56-60°C
Boling Point	498.8°C at 760 mmHg
Flash Point	236°C
Water Solubility	Insoluble in water.
Vapor Presure	2.62E-11mmHg at 25°C
BRN	1880414
Storage Condition	Refrigerator
Sensitive	Light Sensitive
Refractive Index	1.486
MDL	MFCD00041683
In vitro study	10,12-Tricosadiynoic acid-CoA rapidly inhibits ACOX1 activity in a time- and concentration-dependent manner. The activity of ACOX1 decreases by nearly 95% after 5 min of incubation with 10 eq of 10,12-Tricosadiynoic acid-CoA. ACOX1 activity is inhibited only if free 10,12-Tricosadiynoic Acid is activated as the CoA thioester, the substrate form. Inhibition of ACOX1 by 10,12-Tricosadiynoic acid-CoA is irreversible. And the kinetics parameters KI and kinact are calculated to be 680 nm and 3.18 min −1 , respectively. 10,12-Tricosadiynoic acid is the precursor of 10,12-Tricosadiynoic acid-CoA and is transformed into 10,12-Tricosadiynoic acid-CoA by peroxisomal very long chain acyl-CoA synthetase (VLACS) after entering into cells, and it inhibits ACOX1 in vivo. 10,12-Tricosadiynoic acid (500 nM) inhibits acyl-CoA oxidase-1 (ACOX1) activity. 10,12-Tricosadiynoic acid treatment abrogates the protective effect by Sirt5 siRNA.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
FLUKA BRAND F CODES	10-23
HS Code	29161900

biological activity	10,12-Tricosadiynoic acid is a highly specific, selective, acyl-CoA oxidase -1 (ACOX1) inhibitors with high affinity and oral activity. 10,12-tricosadiynoic acid can improve mitochondrial lipid and ROS metabolism, and can be used in the study of metabolic diseases caused by high fat diet or obesity.
Target	Acyl-CoA oxidase-1 (ACOX1).
Animal Model:	Male Wistar rats (210-230 g) fed with high fat diet
Dosage:	100 μg/kg
Administration:	Oral gavage; daily; for 8 weeks
Result:	Reduced hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreased hepatic lipid and ROS contents, reduced body weight gain, and decreased serum triglyceride and insulin levels.

Last Update：2024-04-10 22:29:15

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10,12-TRICOSADIYNOIC ACID

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